Membrane association and destabilization byAggregatibacter actinomycetemcomitansleukotoxin requires changes in secondary structures

Membrane Research in a Global Context Requires Collaboration, not Competition!

membrane research in a global context requires collaboration, not competition!

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Physicochemical Position-Dependent Properties in the Protein Secondary Structures

Background: Establishing theories for designing arbitrary protein structures is complicated and depends on understanding the principles for protein folding, which is affected by applied features. Computer algorithms can reach high precision and stability in computationally designing enzymes and binders by applying informative features obtained from natural structures. Methods: In this study, a ...

Disruption of cellular signaling pathways by daunomycin through destabilization of nonlamellar membrane structures.

Albeit anthracyclines are widely used in the treatment of solid tumors and leukemias, their mechanism of action has not been elucidated. The present study gives relevant information about the role of nonlamellar membrane structures in signaling pathways, which could explain how anthracyclines can exert their cytocidal action without entering the cell [Tritton, T. R. & Yee, G. (1982) Science 217...

Association between blood pressure changes and obesity in over-18

Introduction: Overweight and obesity are risk factors for developing many diseases such as hypertension. Furthermore, obesity indicators such as abdominal height, waist circumference and hip circumference can independently and sometimes more severely lead to blood pressure changes. The objective of this study was to evaluate the association between blood pressure changes and anthropometric in...